<International Circulation>:  What about some new studies that have focused recently on the relationship between arterial stiffness and the endocrine system in essential hypertension patients? Which particular endocrine disorders are related and are there any recent progresses or related studies in this area or this relationship?

    Prof.  Widimsky :I think that high aldosterone renin ratio predicts also a high likelihood of primary aldosteronism and based on usual conventional ideas it seems that high aldosterone ratio predicts further development of primary aldosteronism and a higher aldosterone ratio then the higher the occurrence or likelihood of primary aldosteronism.  And it seems based on recent data it seems that aldosterone renin ratio is highly reproducible within hypertension in the United States and maybe higher， aldosterone renin ratio is more reproducible compared to confirmatory tests used commonly for the detection of primary aldosteronism like saline suppression test or fludrocortisones test.