<International Circulation>:  First I wanted to ask you， with the aldosterone renin ratio， it is a sensitive screening marker in primary aldosteronism and some new studies have shown and demonstrated that it is also related to essential hypertension， so I would like to know if you have a view on the relevance of the aldosterone renin ratio in relation to essential hypertension?

    Prof.  Widimsky : Certainly.  Aldosterone renin ratio is quite a useful marker for the determination of not only secondary form of hypertension mainly primary aldosterone and but also for determination of essential hypertension.   High aldosterone ratio is frequently or highly common in patients with CV hypertension – essential hypertension and based on our results aldosterone ratio to some extent may also predict cardiac complications.  Those patients who have high aldosterone ratio present usually with higher occurrence of target organ damage and based on our data for instance or based on our data on intima media thickness of carotid arteries compared to those with normal aldosterone renin ratio.  It seems that aldosterone renin ratio may carry also some additional risk within the category of essential hypertension patients.